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Cheap Flights from Santiago to Panama City
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Cheap Flights from Santiago to Panama City starting at US$383

Book one-way or return flights from Santiago to Panama City from as little as US$383. Choose from the popular airlines below and book your flight today!

  • One way
  • Round-trip
      • STI06:50
        8h 30m
        1 stop
        PTY14:20
        Sat, Jun 8|Santiago - Panama City|American Airlines
        US$383US$634
        40% OFF
        40% OFF
        US$634US$383
      • STI09:00
        9h 8m
        1 stop
        PTY17:08
        Sat, Jun 1|Santiago - Panama City|Flexflight Aps
        US$408US$634
        36% OFF
        36% OFF
        US$634US$408
      • STI09:00
        9h 8m
        1 stop
        PTY17:08
        Sat, Jun 1|Santiago - Panama City|Euroairlines
        US$411US$634
        35% OFF
        35% OFF
        US$634US$411
      • STI09:00
        5h 52m
        1 stop
        PTY13:52
        Sat, Aug 3|Santiago - Panama City|Euroairlines
        US$413
        US$413
      • STI15:55
        2h 41m
        Direct
        PTY17:36
        Sat, Jun 8|Santiago - Panama City|Copa Airlines
        US$508
        US$508
      • STI15:55
        2h 41m
        Direct
        PTY17:36
        Thu, Jun 13|Santiago - Panama City|Copa Airlines
        US$511
        US$511
      • STI15:55
        2h 41m
        Direct
        PTY17:36
        Tue, Jun 4|Santiago - Panama City|Copa Airlines
        US$515
        US$515
      • STI15:55
        2h 41m
        Direct
        PTY17:36
        Sat, Jun 1|Santiago - Panama City|Copa Airlines
        US$524
        US$524
      • STI15:56
        2h 40m
        Direct
        PTY17:36
        Sat, Aug 3|Santiago - Panama City|Copa Airlines
        US$529
        US$529
      • STI07:00
        8h 20m
        1 stop
        PTY14:20
        Sat, Aug 3|Santiago - Panama City|American Airlines
        US$530
        US$530
      • STI13:00
        3h 5m
        Direct
        PTY14:00
        Wed, May 22|Santiago - Panama City|American Airlines
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Searching for the best last minute flight from Santiago to Panama City? Find one-way or return flights that are affordable and fit your itinerary.

Trip.com monitors the ticket fares of flights from Santiago to Panama City. Stay updated on price trends and snag the best deals for your upcoming trip.

Displayed prices are calculated based on the lowest average weekly prices of the corresponding route on Trip.com.
Cheapest Airlines flying from Santiago to Panama City

View airlines operating flights from Santiago to Panama City. Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

DM Airlines
From US$290
Spirit Airlines
From US$352
Jetblue Airways
From US$375
American Airlines
From US$383
Flexflight Aps
From US$408
Euroairlines
From US$411
Copa Airlines
From US$508
United Airlines
From US$551
Delta Air Lines
From US$587
Silver Airways
From US$747
ANA airlines

Find more flights and airlines

Alternative Routes from Santiago to Panama City

Discover different routes, airlines, and transfers and find the best alternative flights for your journey from Santiago to Panama City.

  • Cheapest
    DM Airlines
    STI
    08:30
    13h 15m
    2 transfer
    PTY
    20:45
    Cibao International Airport - Tocumen International Airport
    Thu, May 16DM Airlines
    US$290
  • DM Airlines
    STI
    08:30
    13h 15m
    2 transfer
    PTY
    20:45
    Cibao International Airport - Tocumen International Airport
    Thu, May 16DM Airlines
    US$290
    Find More Flights

Frequently Asked Questions

  • When to buy flight tickets from Santiago (STI) to Panama City (PTY) the cheapest?

    Airlines adjust prices for flights from Santiago to Panama City based on the date and time of your booking. By analyzing data from all airlines, on Trip.com, you can find the cheapest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • How much is a flight from Santiago (STI) to Panama City (PTY) cost?

    According to Trip.com's data, the lowest price is around US$759.

  • How long is a flight from Santiago (STI) to Panama City (PTY)?

    It takes about 2 hours 40 minutes to fly from Santiago (STI) to Panama City (PTY).

  • What is the transportation method from the main airport to downtown in Panama City?

    • The distance from Tocumen International Airport to downtown is about 16km, by taxi about 30 minutes.
    • The distance from Albrook "Marcos A. Gelabert" International Airport to downtown is about 5km, by taxi about 20 minutes.

  • What are the most popular airlines that fly from Santiago (STI) to Panama City (PTY)?

    Airlines with flights from Santiago (STI) to Panama City (PTY): Copa Airlines.

  • How many airports in Panama City?

How to find a cheap flight from Santiago to Panama City

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from Santiago to Panama City. Book your flights at the right time and save more.
1
Book Early
Once prices are gone, they're gone. Lock in deals while you can!
2
Compare Flight Prices
Compare prices on travel agency and airline websites.
3
Look Out for Deals
Check airline and travel agency websites for latest flight deals
4
Check One-way Fares
Buying two cheap one-way flights can sometimes be a better deal than a round-trip.
5
Try Different Dates
Flying during the week, early in the morning, or late at night can help save money.
6
Use the Trip.com App
Save up to £10 per person when booking your flights on Trip.com
Flight Information from Santiago to Panama City

Cheapest direct flight price

US$383

Cheapest return ticket price

US$324

Cheapest month

January

Peak season for travel

July

Flight distance

1,506.92km

Average flight time

2 hours 40 minutes

Popular airline

Silver Airways

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